Nootropic brain enhancement

Have you wanted to ultimately be smarter than you are, or were at any point in your lifetime? 

Well, now you can buy a new brain at Walmart.

 

Yeah, right.  We aren’t that advanced, yet.

Neuroscience has given us the option of a more productive brain. Supplements of all kinds fill the shelves in all sorts of vitamin sections of stores.  This option, to lead you to that smarter goal, can  increase your productivity, improve concentration and create massive amounts of motivation.

Nootropics.

Nootropics, memory enhancers, neuro enhancers, cognitive enhancers, and intelligence enhancers, are drugs, supplements, nutraceuticals, and functional foods that purportedly improve mental functions such as cognition, memory, intelligence, motivation, attention, and concentration. Nootropics are thought to work by altering the availability of the brain's supply of neurochemicals (neurotransmitters, enzymes, and hormones), by improving the brain's oxygen supply, or by stimulating nerve growth.

Nootropic - having positive effects on organically impaired cognition or nervous system function; said of certain drugs. (http://web.archive.org/web/20080130031824/http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_n_10zPzhtm)

Commonly referenced memory drugs, or nootropics are, Racetams.  These are sometimes cited as having few side-effects with a wide therapeutic window. The well known racetams are piracetam, the oldest and most well-known of the group, aniracetam, oxiracetam, pramiracetam and noopept.  Racetams function to control glutamate receptors.  Glutamate receptors are in the brain. There are two types of glutamate receptors, AMPA and NDMA. The neurotransmitter, glutamate, binds to these receptor sites and assists in learning and memory formation as well as muscle coordination and other important neurological functions.  Other receptors work in coordination with racetams.  Cholingeric receptors bind to acetylcholine, which is another important neurotransmitter involved in cognitive function. This binding process causes increased alertness and sensory perception.

 

 

 

Importantly, racetams aren’t based amphetamine chemical structures like the “smart drug” ADHD medication.  Some will use these illegally, and end up having an addiction.  Racetams are sage.

One experiment using the nootrophic piracetam was printed in the Georgian Med News. 2013 Jul-Aug;(220-221):64-71.  Study of acetylsalicylic Acid role in the potentiation of antiamnesic and neuroprotective properties of piracetam in rats with alloxan diabetes. 

“Co-administration of piracetam with acetylsalicylic acid was accompanied by an expressed antiamnetic potential - the reduction of early markers of proteins degradation (aldehydephenylhydrazones, APH) by 21,7% (p<0,05) and late markers of proteins degradation (ketonephenylhydrazones, KPH) by 23,8% (p<0,001) was noted. This combination was 15,7% (p<0,05) more active than piracetam according to the effect upon KPH. NO2-/NO3- level was also decreased by 30,3% (p<0,05) in comparison with alloxan-diabetic rats. The significant anti-platelet effect was observed: degree of collagen-induced platelet aggregation was reduced by 56,8% (p<0,01), ADP (5 μmol/l)-induced - by 31,7% (p<0,01), ADP (20 μmol/l)-induced - by 47,3% (p<0,01) as compared to the hyperglycemic rats. Such an increase in nootropic activity of piracetam may be assumed to be directly related to the ability of acetylsalicylic acid to improve microcirculation in the ischemic areas of the brain in diabetes and probably to its neuroprotective potential.”

Neurological advances have put you in the place to make you a smarter individual.  We go to gyms like it is our second nature.  Why not exercise our most inspiring part of the body?

Nootropics.



 

Netflix tv streaming

     Is there too many things to do?
Are you so wired up that you need to wire down?

     Tv always seems to play the same show, rerun after rerun, until you unknowingly laugh at it.

     Cable is old, and satellite is getting there.

     If you want the newest way to watch the same show, check out Netflix, via tv streaming.

             "Netflix, Inc. is an American provider of on-demand Internet streaming media available to North and South America, the Caribbean, United Kingdom, Ireland, Sweden, Denmark, Norway, Finland, the Netherlands, and flat rate DVD-by-mail in the United States, where mailed DVDs are sent via Permit Reply Mail.The company was established in 1997 and is headquartered in Los Gatos, California.(www.wikipedia.com)"

     Streaming media is multimedia that is constantly received by and presented to an end-user while being delivered by a provider. Its verb form, "to stream", refers to the process of delivering media in this manner; the term refers to the delivery method of the medium rather than the medium itself.A client media player can begin playing the data (such as a movie) before the entire file has been transmitted. An example of streaming media is Roku.

     One might infer that, "regular old tv is already free". Shows on Roku, and other devices in the genre, are very different from regular tv shows.  These vids are on demand, with no commercials, you can fast forward, you can rewind, and pause, etc.

     "Just between you and me...there are some great shows on netflix that couldn't be found on other channels." Netflix originals are great, too.  "HOUSE OF CARDS" has exceeded all possible expectations.

     All in all, Netflix is a great way to waste large amounts of time.

     Unwind with a commercial free, relatively cheap, wide plethora of choices on streaming media.

Not enough sleep

     Good morning. 
    
     This is a phrase we use so much that it is virtually devoid of any meaning.  It shouldn't be devoid of meaning, though.  This should follow behind your waking up, bright eyes and bushy tailed, doctor recommended 8 hours over night sleep.

     The truth is that it is devoid of meaning because so many Americans suffer from sleep deprivation.  Rest consists of less than six hours, and sometimes three or four hours.  The statement becomes a fuzzy, "g'mornin'...".

     Coffee?...

     Sleep deprivation is defined as:
     a condition of not having enough sleep.  It can be either chronic or acute. 

               "In the long term, the clinical consequences of untreated sleep disorders are large indeed. They are associated with numerous, serious medical illnesses, including:

High blood pressure
Heart attack
Heart failure
Stroke
Obesity
Psychiatric problems, including depression and other mood disorders
Attention Deficit Disorder (ADD)
Mental impairment
Fetal and childhood growth retardation
Injury from accidents
Disruption of bed partner's sleep quality
Poor quality of life
          (Chronic Sleep Deprivation and Health Effects
http://www.m.webmd.com/sleep-disorders/features/important-sleep-habits)"

               "A recent North Carolina study revealed that sleep deprivation creates increased ghrelin levels thereby sending signals to your brain that you’re hungry. Maintain proper sleeping habits by getting to bed at the same time each night, and creating a dark, comfortable atmosphere in your bedroom. Aim for eight hours. You’ll not only feel reenergized, but it’ll also positively impact on your metabolism. 
          (http://m.mensfitness.com/training/lose-weight/5-things-to-know-about-boosting-your-metabolism)"

     We should boldly be able to say, "Good morning!", with a huge smile.  The smile then entails that, wow this person has had a great nights' rest. 

     Lets deprive ourselves of sleep deprivation.

Round Research

     The C. elegans is a is a free-living, transparent nematode, also called a round worm, about 1 mm in length. The C. elegant thrives in temperate soil environments.

     This worm has been especially integral in science in the past decade. One reason is simply because of its short life span. In 2002, the Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner, H. Robert Horvitz and John Sulston for their work on the genetics of organ development and programmed cell death in C. elegans. The 2006 Nobel Prize in Physiology or Medicine was awarded to Andrew Fire and Craig C. Mello for their discovery of RNA interference in C. elegans. The list is virtually bottomless. Most recently, not the least interesting, has been reported in the popular news journal, Plosbiology. (http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001613) " Anthranilate Fluorescence Marks a Calcium-Propagated Necrotic Wave That Promotes Organismal Death in C. elegans."

    "Oxidative and Thermal Stress Do Not Increase Blue Fluorescence.  Lipofuscin is formed through accumulation of oxidatively damaged proteins and lipids. For example, raised oxygen level (40% O2) increases lipofuscin levels in human fibroblasts. To probe whether the blue fluorescent material in C. elegans gut granules is lipofuscin, we exposed them to normobaric hyperoxia (90% O2), and elevated iron levels. Both treatments significantly increased protein oxidative damage but neither increased blue fluorescence levels. Elevated expression of hsp-4::gfp is indicative of the unfolded protein response, symptomatic of protein damage. Heat shock increased hsp-4::gfp expression but not blue fluorescence. These results imply that C. elegans blue fluorescence is not generated by oxidative damage, suggesting that it is not lipofuscin. In this study, we have shown that conserved mechanisms underpinning neuronal necrosis can also contribute to organismal death. In so doing we provide the first insights into the last biological events in the life history of C. elegans: those leading to its final demise. Identification of an endogenous fluorescent marker of death led us to discover a calcium-generated wave of necrotic cell death that occurs during, and can contribute to, organismal death. We have also chemically defined the source of the endogenous blue fluorescence that is a salient characteristic of C. elegans. C. elegans Blue Fluorescence Is Not Lipofuscin. In this study we have defined a new phenomenon, death fluorescence, which may be useful in future as a marker of death in lifespan assays. While DF means that blue fluorescence cannot be used as a biomarker of aging we confirm that red fluorescence does increase with age. Moreover, tdo-2(RNAi) can be used to abrogate blue intestinal fluorescence to aid the viewing of expression of intestinally expressed fluorescent reporters. Materials and Methods Worm Maintenance and Strains Standard C. elegans strain maintenance and genetic manipulations were used. All strains were grown at 20°C on NGM plates seeded with E. coli OP50 as food source unless otherwise specified. N2 (Bristol) was the wild-type. Oxidative Stress Assays: Hyperoxia treatment. Young N2 adults were placed in either 90% O2 or air at 25°C for 5 d on 10 µM FUdR (fluorodeoxyuridine), OP50 seeded NGM plates. Iron treatment. Heat shock treatment. Carbonyl measurement. Blue fluorescence measurements. Microfluorimetry Time-lapse photography. Single-animal vermiculture. C. elegans Killing Assays and DF Measurements Worms were killed in three ways, all of which result in bursts of blue fluorescence of similar magnitude."

     The C. elegans is important to the point that around the world many hundreds of scientists are working full time investigating its biology.

     An international consortium of laboratories collaborated on a project to sequence the entire 100,000,000 bases of DNA found out that 40% of its genes have human matches.

     It was the first worm to be sequenced. This worm is only 1 mm, but it is of gargantuan importance.

Leap Wireless Rimmed by AT&T

     No more contract, no more contracts, no more contracts.

     Done.

     Buying a phone used to be a long thought process, because you had to be stuck with it for the next year or two.  By then, the phone looked like a big, dirty rock in your pocket.

     Now, the big names are turning toward NO CONTRACT.  Cricket Wireless made the bar drop.  The trend made AT&T and T-Mobile reverse their product lines.  Verizon, too.  They had to figure out where the money would come in at.  INSTALLMENT PAYMENTS.

                    “Chances are that the carriers will still make some money on hardware sales. They buy in bulk and would get discounts. Reselling for list price will possibly let them make more money than they used to. Consumers will likely look for cheaper phone retailers and just get the service without the need for new hardware (http://www.cbsnews.com/8301-505124_162-57593983/cheaper-mobile-is-coming-at-a-price/).”

     In order for AT&T to catch the trend they just purchased the parent company of Cricket Wireless.  The lesser company was in competition with MetroPCS.  Their sales were spectrum in terms of city to city.  New customer sprang from lower prices and no burden of one and two year contracts.   AT&T didn’t view the parent company of Cricket, Leap Wireless as a threat at all.  The companies had different products. 

     AT&T announced their intentions to buy Leap Wireless for a nice $1.2 billion.  Those little cheap, lime green buildings are worth $1.2 billion, now.  Only in America.  If you knew so, your stocks just took a 112% leap, recently.  Very nice.

     Why?  You could ask this question.

                    “This not only improves our spectrum position, it advances our offerings in prepaid service,” says Brad Burns, a spokesman for AT&T. “We’ll make the prepaid market more competitive. Leap’s customers will be able to ride on our fast LTE network.” AT&T will win even more spectrum with the deal in the densely populated areas where it’s having difficulty meeting current demand (http://www.businessweek.com/articles/2013-07-15/at-and-t-buys-leap-for-spectrum-gets-low-paying-customers).”

     Spectrum is the name of the game.  Having vast amounts of spectrum is the key.  Spectrum is the most valuable resource in the mobile phone industry.  Who wants a phone where the calls drop, and you miss messages, etc.  AT&T will have to reinvent their product line on a small level.

     T-mobile on the other pink hand has sucked up MetroPCS. 

                    “The merger was announced in October 2012. According to the proposal, T-Mobile's parent company, Deutsche Telekom, will pay $1.5 billion in cash for a 74 percent stake in the company. MetroPCS's shareholders will own the other 26 percent of the combined company. The new company will be called T-Mobile.  Unlike AT&T's proposed $39 billion bid to acquire T-Mobile in 2011, this merger has had a relatively smooth ride through the regulatory approval process. Last week, the Justice Department allowed a critical waiting period required under antitrust law to lapse, effectively signaling its support for the merger. The Justice Department's statement today simply means that the agency did not find any reason to block the merger due to antitrust concerns.  And the FCC has now given its official stamp of approval, effectively stating that the merger is within the public interest. The agency will now allow the transfer of wireless licenses as part of the deal. (http://news.cnet.com/8301-13578_3-57573867-38/feds-approve-t-mobile-merger-with-metropcs/)”

     Awesome, no more contracts.  It isn’t going to hurt anymore.  You can cut your cell phone bills and worries without missing all the new technology.

CANCER

“About 1,660,290 new cancer cases are expected to be diagnosed in 2013, and in 2013 about 580,350 Americans are projected to die of cancer, almost 1,600 people a day. Cancer remains the second most common cause of death in the US, accounting for nearly 1 of every 4 deaths. (http://www.cancer.org/index) ”

 

     This statistic isn’t very detailed either.  There are several different types of cancer; none of which diminish the uninviting reality of the disease.

 

 

     You might ask: “Well, what is cancer?”

     Cancer is defined as a malignancy.  This malignancy is an abnormal growth of cells.  “The growth and differentiation of cells in the body are normally strictly controlled.  Thus, with few exceptions, cells in the adult body are largely quiescent.  However, for a variety of reason, a cell may be made to proliferate uncontrollably to form a tumor (Wiley Asia Student Ed.  FUNDAMENTALS OF BIOCHEMISTRY. Voet 2006).” This unwanted growth that damages healthy organs is the uncontrolled malignancy.  The growth then continues to spread toward other healthy organs.  Cancer symptoms vary widely based on the type of cancer. Cancer treatment could include chemotherapy, radiation, and/or surgery.

     The best way to treat cancer is through early detection.  The diagnosis begins with routine self-exam or physical exams. “If the diagnosis is positive (cancer is present), other tests are performed to provide specific information about the cancer. This essential follow-up phase of diagnosis is called staging. The most important thing doctors need to know is whether cancer has spread from one area of the body to another. If the initial diagnosis is negative for cancer and symptoms persist, further tests may be needed. If the biopsy is positive for cancer, be sure to seek a confirming opinion by a doctor who specializes in cancer treatment before any treatment is started (http://www.webmd.com/cancer/default.htm).”

 

Cancer research is ongoing.  The cure isn’t far away.  We keep praying.  New developments are constantly on the horizon.  A recent headline on www.newscientist.com read, Antibody wakes up T-cells to make cancer vanish , 17:07 04 June 2013 by Andy Coghlan

 

 

     With this progress researchers learned how to wake up otherwise slumbering T-cells.  The T-cells are dosing off and permitting unrecognized cells to proliferate.  Full functioning T-cells will instantly recognize and destroy foreign material in the body.  Tumor cells became wise to that fact, though.  Tumor cells evolved and masked themselves with a sprout surface molecule called a ligand.  Ligands bind.  On tumor cells, the ligand binds and activates a receptor on the T-cell called PD-1.  The PD-1 receptor is an almost perfect mask.  The T-cells can’t recognize foreign material.  The immune system continues to produce tissues with the cancer as if everything were normal.  The abovementioned antibodies can unmask the cancer cell by blocking the ligand’s interaction with PD-1 ligand.  Then, certainly, the T-cells can resume destroying the foreign material eradicating the cancer.  Research Lambrolizumab, and Nivolumab for more details.

     One day the only subject that springs to mind on the term CANCER is the astrological sign.

 

Live in your vacation Dream

     Your vacation dreams are always 100% stress free.  Imagine being sleep while you are awake.

     Stress affects everyone at any given time, when you are at work, at home, at the gym, etc. Stress can become a serious ailment.  When in excessive amounts, stress can lead to physical ailments such as ulcers or mental impairment such as depression. To avoid developing such conditions it is important to effectively manage stress. Managing stress begins with defining the cause of your stress. Personal situations can cause stress, but the environment can also be a main cause of stress.   Where are you living?  Where are you sleeping?  Where is your neighborhood?

     When you are totally relaxed and in a deep sleep pay attention to your body, and your frame of mind.  Listen and learn from your dreams.  Set some relaxing goals, and don’t be afraid to day dream, sometimes.  When you have a really great dream try to remember it by writing it down after you wake up.  Look at the surroundings involved.  Was the dream in a house? 

Dreams relating to a house often refers to various aspects of the Self. When trying to analyze the house in your dream, consider also how the house is kept and the condition of it. The rooms in the house relate to facets of your personality

http://www.dreammoods.com/dreamthemes/house.html

 

     Was the dream in Las Vegas?  Well, for $7.9 million you could own a home just off the Vegas strip with a fully equipped, customized casino where the house never wins.   Is that a fabulous dream, or what?  Some retired old guy, already living his dream,  says that the worst thing about living in a Las Vegas hotel penthouse  is a bad day in the casino.  His own private casino.

 

                        

     Living in a sugar coated candy cloud can happen to you.  Take these inspiring words for example:

 

     Right now is a miracle. Right now is the only moment guaranteed to us. Right now is life. So let us stop thinking about how great things will be in the future. Stop dwelling on what did or didn't happen in the past. Learn to be in the here and now and experience life as its happening. Appreciate the world for the beauty that it holds, right now. Lets start noticing and living in the present !! 

 Glen Rambharack quotes 

 

     Just get you a nice two room tent and go back to the hunting and gathering days.  Is that your dream?  At $20,000 for a little plot in rural New York, what would you like to put on it?  If you are looking for a great hunting spot just remember we are all neighbors with somebody, the deer, turkey, fox and rabbits all live there too!

 

 

 

 

 

 

 

     Americans are finding it more difficult to relax, especially with economy changes and fewer employees.  Fewer employees means more work, individually. Advances in technology have helped in many ways but it has also made it easier for our employer, clients and co-workers to reach us.  Whisk yourself away, permanently.  Build that at-home office you have been dreaming of.

      Live in your vacation dream.