Sunday, February 26, 2012

Plan B

There are said to be side effects when attempting to be mature after being immature.  When using this emergency contraceptive product the female may have:
  • Changes in her period
  • Nausea
  • Lower abdominal pain
  • Fatigue
  • Headache
  • Dizziness
  • Breast tenderness

The box tells the patient:  “…you may have an ectopic pregnancy and should get immediate medical attention. (http://planbonestep.com/where-to-get-plan-b.aspx, 2/26/2012)”
Lots of these FAQS could scare you.  Studies are being conducted periodically.

For example: one such study showed that the adjusted odds ratio for gallbladder disease comparing drospirenone and levonorgestrel OCs to nonexposure were 0.9 [95% confidence interval (CI) 0.7-1.1] and 1.0 (95% CI 0.9-1.1), respectively.  The research concluded, that there is no evidence in these data that drospirenone- or levonorgestrel-containing OC use confers an increased risk of gallbladder disease compared to women not currently exposed to an OC. Nor is use of drospirenone OCs associated with a higher risk of gallbladder disease than use of levonorgestrel-containing OCs. (Contraception. 2012 Feb 9. Drospirenone- and levonorgestrel-containing oral contraceptives and the risk of gallbladder disease.)
Another study demonstrated results from research aiming to examine the effect of COC usage on CYP3A4/5 activity in obese women.  Thirty-four, reproductive-aged (18-35 years old) obese (body mass. The methods utilized index, BMI >30 kg/m(2) ) women were placed on a combination oral contraceptive pill containing 20 mcg Ethinyl Estradiol/100 mcg Levonorgestrel for 21 days starting at the onset of menses. Midazolam pharmacokinetic study was conducted prior to initiation and after 21 days of COC treatment. Serial blood samples were collected and plasma concentrations of midazolam were measured using liquid chromatography tandem mass spectrometry. Pharmacokinetic parameters were estimates using  Midazolam clearance, a surrogate measure of noncompartmental method. Results: CYP3A4/5 activity, was significantly decreased upon COC use (63.3L/hr vs. 53.9L/hr; p<0.05). A median decrease of 5.6 L/hr (C.I: -4.1 to 13.3 L/hr) was observed. However, the magnitude of change was similar to that reported in  Although we hypothesized that obesity exposure normal BMI women. Conclusions: might amplify the impact on CYP3A4/5 activity in COC users, we found that this was not the case. This finding is reassuring regarding potential additional drug-drug interactions in obese COC users as CYP3A4/5 is a major player in the metabolism of many marketed drugs.  (Effect of Ethinyl estradiol/ Levonorgestrel combined oral contraceptive on the activity of Cytochrome P4503A in obese women., Edelman A, Munar M, Elman MR, Koop D, Cherala G., Br J Clin Pharmacol. 2012 Feb 2.)
Form an intelligent hypothesis.
Assimilate positive goals.

Wednesday, February 1, 2012

Momentum to Desirable Customer Service

Where does customer service make a huge difference?  Is it when you get that HACK DOUBLE WITH EXTRA CHEESE, and they give you the ‘special’ one without sauce?
Or, is it when you really are spending a little more change than a dollar bill.  Approach a place of business with a few stacks, and then let somebody tell you that you need to hold your horses for a darn minute, senor.
There was an example:
Car dealerships, such as Momentum BMW, offer many automotive products and services to their area customers. The Managers need to be extremely knowledgeable of quality new BMW vehicles, used cars, and value priced parts.
“Momentum carries a comprehensive line of new 2011 - 2012  BMW vehicles, including the X5, M3, 3-Series, 5-Series and 7-Series, making us a good choice as your Houston BMW car dealer.(Momentum BMW-Houston 2/1/2012)”
World-class customer service would fulfill ambitious missions with services including trust, originality, and customers experiencing their dream being brought into mortal wellness. A Manager’s team has to be a strong, and committed staff with experience surpassing the mere satisfaction of the customers' needs.  Flying low passed satisfaction in businesses like Momentum involves spending time in the community, volunteering donations to Houston Children's Charity, Be an Angel Foundation, and Children's Advocates.
Don’t underestimate that momentum = mass • velocity.  The details of the equation are Mass being customer service, and Velocity being overall sales.  Read those plates.
Customers going to buy a car usually expect that after you've agreed to a selling price - whether through negotiating or the Internet or the Fleet Department -- you'll be herded into the Business Office. There, you have to be aggressive. Customers keep in the forefront of their mind that the Business Manager is actually a salesperson working on commission so the car buying game is not over.  “WOULD YOU LIKE TO PLAY A GAME?”
We, as managers, understand that a balance of confidence, humility and knowledge, together with integrity and skill, will make the ideal businessman/woman.

Maintain mass and you will maximize velocity, towards a more than equal customer service experience.